The (Non)Reproducibility Crisis, Part 1
John Ioannidis’s 2005 paper, “Why most published research findings are false”[1] set off a cascade of discussion, despite its impenetrability, not least because of its sensational title. Concerns about non-reproducibility have been… Read More
Laser-induced Choroidal Neovascularization in the Mini Pig
A validated model for posterior segment proliferative ocular disease at CBI CBI is known throughout the Industry as a premier ocular preclinical CRO. For over 10 years, we have offered established in-house… Read More
Thermal and UV Burn Modeling at CBI
Thermal and UV burns represent an unmet medical need, particularly in defense or military settings. CBI has a number of humane, validated and optimized superficial, partial thickness and full thickness burn models… Read More
Rabbit Hypertrophic Scar or Keloid Model
At CBI we offer the Rabbit Hypertrophic Scar or Keloid Model. This is a validated and established model that assessed the effects of various test articles on scar formation or resolution. In… Read More
New Capabilities: Histology, Immunohistochemistry and Histomorphometry at CBI
The CBI histology laboratory is offering some new capabilities! In addition to our standard histology, pathology, immunohistochemistry and histomorphometry in both a research and GLP environment, we have just presented a poster… Read More
Postnatal Hyperoxia-induced Lung Injury at CBI
Neonatal hyper-oxygenation has been demonstrated to produce bronchopulmonary dysplasia. Developing treatments for this syndrome is an unmet medical need. Here at CBI, we have developed and validated robust models for this syndrome, for the… Read More
Cancer Immunotherapy-Preclinical Toxicology
Cancer immunotherapy represents a new and promising area of treatment of cancer. This is an exciting field and is overseen by the FDA CBER OCTGT division. A number of new drugs have… Read More
Preclinical Otic Studies at CBI
We have been offering a variety of otic studies to support test article efficacy, toxicity and pharmacokinetics, particularly to support regulatory submissions, CBI is one of the few CROs which provide specialized… Read More
Cutting Edge Preclinical Infection Modeling
We have been doing some fascinating and cutting edge anti-infective work. Not only are we conducting our standard workhorse models, such as Mouse Protection Test and Neutropenic Thigh, but we have been… Read More
Atopic Dermatitis Model at CBI
CBI offers a robust validated murine model of atopic dermatitis characterized by edema, perivascular eosinophil and monocyte inflammation, and increased epidermal thickness in taped stripped skin that has been repeatedly sensitized with… Read More