Thermal and UV burns represent an unmet medical need, particularly in defense or military settings.  CBI has a number of humane, validated and optimized superficial, partial thickness and full thickness burn models in rodents and pigs, including mini and Duroc pigs.  We have evaluated a number of therapeutic regimes including biologics and stem cell treatments as well as small molecules and immunomodulatory agents. We also conduct UV burn modeling, particularly in rodents. Methods of assessment include:

• Wound healing progression with digital image analysis of wound size and closure
• Draize scoring
• Transepidermal water loss
• Body temperature and body weights, food consumption
• Hematology and clinical chemistry
• Serum and tissue markers of inflammation
• Serial biopsies
• Histopathology and photomicroscopy
• Special stains and immunohistochemistry
• Histomorphometry
• Custom designs upon request
• Complete, timely reporting suitable for regulatory submission (GLP and non-GLP studiesFor more detailed information visit our white paper and ppt presentation and our blog.

Published manuscript: FoubersP, BarillasS, GonzalezAD, AlfonsoZ, ZhaoS, HakimI, MeschterC, TenenhausM, FraserJK. Uncultured adipose-derived regenerative cells (ADRCs) seeded in collagen scaffold improves dermal regeneration, enhancing early vascularization and structural organization following thermal burns. Burns. Nov;41(7):1504-16, 2015