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Cutting Edge Preclinical Infection Modeling

By Carol Meschter • February 17, 2017 • CBI

We have been doing some fascinating and cutting edge anti-infective work.  Not only are we conducting our standard workhorse models, such as Mouse Protection Test and Neutropenic Thigh, but we have been developing some customized and sophisticated infection models.

Suture Infection in Rats.  We developed and conducted a number of studies evaluating dermal staph infections associated with different sorts of unique suture technology.  The histologic section shows the deep dermal suture abscess in an untreated lesion.

Infected suture abscess

Infected suture abscess

Bacterial Endocarditis in Rabbits. We optimized and conducted a number of studies evaluating  test articles in  a model of vegetative valvular endocarditis with  staph infection in rabbits.  We  use a guided imaging method to place the intracardiac catheter.

Ocular Keratitis and Conjunctivitis in Rabbits. We optimized and conducted a number of studies evaluating treatment regimes in bacterial and viral infection of the damaged cornea and conjunctiva in rabbits.  In addition to creating the corneal lesion, we used sophisticated imaging of the cornea and anterior segment.

Contact us for more information on our infection modeling.

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Atopic Dermatitis Model at CBI
Preclinical Otic Studies at CBI

About the Author

Carol Meschter

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    MEET CAROL MESCHTER

    MEET CAROL MESCHTER
    Carol Meschter, DVM, PhD, DACVP is a founder of Comparative Biosciences, Inc. She is an experienced board-certified veterinary pathologist with expertise in toxicology and animal models. She has over 100 publications and is a reviewer for several major journals. She is a scientific editorial reviewer for Toxicologic Pathology, Veterinary Pathology, AVMA Journal, AJVR, J Applied Immunology, and has over 100 publications.

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