Atopic Dermatitis (AD) is an inflammatory skin disease that frequently occurs in subjects with personal or family history of atopic disease. Mechanical injury to the skin by scratching is an important feature of AD and has been shown to induce local expression of IL-10 in patients.
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Passive Heymann nephritis in rats resembles membranous nephropathy in man. It is induced by injection of sheep antibody to rat proximal tubular epithelial cell brush border antigen (anti-Fx1A). This is a robust and validated model at CBI.
Hypertrophic scar formations, a creation of a circular lesion with removal of the perichondrium, elicits a proliferative fibrosis resulting in scar formation on the rabbit ear.
Psoriasis is a chronic skin condition associated with multiple contributing factors including autoimmune disease. The imiquimod-induced Psoriasis model is particularly translational into the clinic as it has many of the significant markers of human disease, including histopathology of lesions and strong activation of the immune system.