Four hypertrophic scars on the ventral side of a rabbit’s ear 4 weeks’ post-wound.


Hypertrophic Scar Formation in Rabbits

Hypertrophic scar (HS) formation is a skin fibroproliferative disease that occurs following a cutaneous injury, leading to functional and cosmetic impairment. To date, few therapeutic treatments exhibit satisfactory outcomes.
Hypertrophic scar (HS) formation is a common complication of wound healing, particularly after burn injuries. HSs are raised, red, rigid, and responsible for serious functional and cosmetic problems. The underlying mechanisms of scar formation are complicated, and the process may be affected by multiple factors.


At CBI, an example of a standard Hypertrophic Scar Formation study, we first create a circular lesion with removal of the perichondrium elicits a proliferative fibrosis resulting in scar formation on the rabbit ear.

• This lesion can be measured and effects of test article determined

• Typical study setup:

• 6 weeks with dosing at day of wound formation

• After formation of scar (~3 weeks) with 3-4 weeks treatment

• With 2-3x weekly assessments and followed by histopathology for each

• Test article may be applied topically or intralesion injection

• Vehicle and test article applied to lesions


About Hypertrophic Scar Formation Studies

At CBI, we have a bold vision – Hypertrophic scars are benign and not harmful to a person’s general health. They do not develop into skin cancer. A hypertrophic scar will often regress completely between 6 months and 3 years after it first appears.


About Histopathologic Scores

Histopathologic scoring is a tool by which semi-quantitative data can be obtained from tissues. Initially, a thorough understanding of the experimental design, study objectives and methods are required to allow the pathologist to appropriately examine tissues and develop lesion scoring approaches.

Comparative Biosciences, Inc’s.
Hypertrophic Scar Formation Studies support the development of your candidate therapeutic antibodies by providing a powerful immunohistochemical assessment of potential cross-reactivity with a range of animal tissue. CBI has all the organizations defined in the relevant FDA and EMA submissions in accordance with the FDA’s recommendation and is in full compliance with local legal regulations and ethical norms.
Scars form when the dermis (deep, thick layer of skin) is damaged. The body forms new collagen fibers (a naturally occurring protein in the body) to mend the damage, resulting in a scar. The new scar tissue will have a different texture and quality than the surrounding tissue.


Contact Comparative Biosciences, Inc. to discuss a scientific study program for all Studies and Services.

Comparative Biosciences, Inc. · Phone: 408.738.9260