Thermal and UV burns represent an unmet medical need, particularly in defense or military settings.  CBI has a number of humane, validated and optimized superficial, partial thickness and full thickness burn models in rodents and pigs, including mini and Duroc pigs.  We have evaluated a number of therapeutic regimes including biologics and stem cell treatments as well as small molecules and immunomodulatory agents.

Methods of assessment include:

  • Wound healing progression with digital image analysis of wound size and closure
  • Draize scoring
  • Transepidermal water loss
  • Body temperature and body weights, food consumption
  • Hematology and clinical chemistry
  • Serum and tissue markers of inflammation
  • Serial biopsies
  • Histopathology and photomicroscopy
  • Special stains and immunohistochemistry
  • Histomorphometry
  • Custom upon request

Complete, timely reporting suitable for regulatory submission (GLP and non-GLP studies).

For more detailed information visit our white paper, download our presentation and our blog.

Thermal Burn Modeling
Histologic section of superficial partial thickness dermal burn in minipig demonstrating blister formation with inflammation and subjacent thermal collagen damage. HE 200x.
Thermal Burn Modeling
Histologic section of deep full thickness dermal burn in minipig demonstrating total epithelial loss, deep and severe collagen damage and damage to the underlying adipose tissue. HE 40x.

Types of Burns

  • Superficial (1st degree)
  • Partial thickness, superficial and deep (2nd degree)
  • Full thickness (3rd degree)
  • Vertical and progression
  • UVB-induced dermal irritation and burns (1st–2nd degree)

Thermal Burn Modeling Therapies

  • Topical or systemic administration
  • Escharotomy and debridement
  • Stem cell therapies
  • Autologous cells
  • Small molecules
  • Biologics
  • Bandaging or wound dressings
  • Sealants
  • Split and full thickness grafting

For more information on our UV burn models, download our presentation.

Thermal Burn Modeling Endpoints

  • Wound healing progression
  • OCT
  • Laser Doppler blood flow
  • Draize scoring
  • Transepidermal water loss
  • Digital image analysis of wound size and closure
  • Body temperature
  • Body weights
  • Hematology and clinical chemistry
  • Serum and tissue markers of inflammation
  • Serial biopsies
  • Histopathology and photomicroscopy
  • Special stains and immunohistochemistry
  • Histomorphometry
  • ELISA
  • Custom upon request
  • Complete, timely reporting suitable for regulatory submission (GLP and non-GLP studies)