Fibrotic disorders are serious disorders of unmet medical need. CBI provides several robust and validated models for fibrosis and scar formation in many models as well as a variety of in vivo, in vitro and histologic methods to support assessment of efficacy. Histologic special stains include trichrome, sirius red, smooth muscle actin, vimentin, collagen IHC and other stains to support histopathologic assessment of tissues.
- Bleomycin-induced pulmonary and dermal inflammation and fibrosis
- Thermal and UV burns
- Burn-induced dermal scarring and fibrosis
- Dermal grafting and wound healing
- Full and split thickness dermal fibrosis and scar formation
- Hepatic fibrosis (CCL4, NASH, ethanol)
- Hypertrophic scar formation
- Hyperoxic Bronchopulmonary Dysplasia
- Monocrotaline-induced pulmonary hypertension and inflammation
- Myocardial-doxarubicin-induced fibrosis
- Myositis and nerve crush injury
- Renal fibrosis and Heymann-Nephritis
For more information on our dermal burn models, please visit our Dermal Burn Modeling page.
Or check out our presentation on CBI’s Fibrosis Modeling capabilites.