Fibrosis Pharmacology

Fibrotic disorders are serious disorders of unmet medical need. Diseases such as keloid scar formation, burn contraction, pulmonary fibrosis, doxarubicin cardiac fibrosis, scleroderma, renal fibrosis, hepatic fibrosis, nerve, marimastat-induced cartilage and muscle crush injury and Heymann Nephritis are important diseases with fibrotic components.

CBI provides comprehensive variety of robust and validated models for fibrosis and scar formation in many models as well as a variety of in vivo, in vitro and histologic methods to support assessment of efficacy. Histologic special stains include trichrome, sirius red, picrosirius red, Movat’s pentochrome,  PAS, Gomori’s, van Gieson’s, Verhoeff’s,  and others.  IHC stains include elastin, endothelium, SMA, vimentin, VWF, collagen and other stains to support histopathologic assessment of tissues.

CBI also offers digital image analysis and histomorphometric assessment of fibrotic change and in vitro bioassays of collagen formation. These are useful and powerful tools to assess the therapeutic effects of various test articles on fibrotic changes.  CBI also offers OCT analysis of fibrotic change– this is particularly useful in dermal fibrosis and sclerodermal models. Silhouette photography is also a powerful tool to assess lesion size and vascularization.

CBI offers multiple species, including various strains of mice and rats, guinea pigs, hamsters, rabbits, dogs and pigs, especially, Duroc hogs that are particularly useful in fibrosis modeling.

Fibrosis Models

For more information on our dermal burn models, please visit our Dermal Burn Modeling page.

Or check out our presentation on CBI’s Fibrosis Modeling capabilites.