Browsing All Posts By

Carol Meschter


Toxicologic and Histopathologic Peer Review

By On August 28, 2017

Histopathologic Peer Review (PR) is an important tool in aiding quality and accuracy in the histopathologic assessment of toxicology studies. The peer review verifies and improves the accuracy and quality of pathology… Read More


The (Non)Reproducibility Crisis, Part 4

By On August 18, 2017

Harris cites numerous examples of Type I error (also known as false positives) in efficacy studies throughout the book—i.e., drugs that worked in disease models but then failed in human trials.  Chapter… Read More


The (Non)Reproducibility Crisis, Part 3

By On August 9, 2017

In our previous post, we discussed NPR science journalist Richard Harris’s general critique of animal research in his book Rigor Mortis, but there is more to be said.  If animal models are… Read More


The (Non)Reproducibility Crisis, Part 2

By On August 2, 2017

In Part 1 of this series, we gave a general introduction to the problem of non-reproducibility of preclinical studies and some reasons why CROs including Comparative Biosciences are somewhat immune to it.… Read More


The (Non)Reproducibility Crisis, Part 1

By On July 25, 2017

John Ioannidis’s 2005 paper, “Why most published research findings are false”[1] set off a cascade of discussion, despite its impenetrability, not least because of its sensational title.  Concerns about non-reproducibility have been… Read More


Laser-induced Choroidal Neovascularization in the Mini Pig

By On May 23, 2017

A validated model for posterior segment proliferative ocular disease at CBI CBI is known throughout the Industry as a premier ocular preclinical CRO.  For over 10 years, we have offered established in-house… Read More


Thermal and UV Burn Modeling at CBI

By On March 24, 2017

Thermal and UV burns represent an unmet medical need, particularly in defense or military settings.  CBI has a number of humane, validated and optimized superficial, partial thickness and full thickness burn models… Read More


Rabbit Hypertrophic Scar or Keloid Model

By On March 23, 2017

At CBI we offer the Rabbit Hypertrophic Scar or Keloid Model.  This is a validated and established model that assessed the effects of various test articles on scar formation or resolution.  In… Read More


New Capabilities: Histology, Immunohistochemistry and Histomorphometry at CBI

By On March 15, 2017

The CBI histology laboratory is offering some new capabilities!  In addition to our standard histology, pathology, immunohistochemistry and histomorphometry in both a research and GLP environment, we have just presented a poster… Read More


Postnatal Hyperoxia-induced Lung Injury at CBI

By On March 14, 2017

Neonatal hyper-oxygenation has been demonstrated to produce bronchopulmonary dysplasia. Developing treatments for this syndrome is an unmet medical need. Here at CBI, we have developed and validated robust models for this syndrome, for the… Read More