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Intraocular Lens Implantation Preclinical Models at CBI

By On January 10, 2019

CBI provides a range of sophisticated and customized intraocular implant models.  We are offering intraocular lens implantation surgery for cataract treatment particularly in both pigmented and albino rabbits. Our DACVO board-certified ocular… Read More


Histopathology on Human Muscle Biopsies from patients affected with a Glycogen Storage Disease

By On November 14, 2018

Provided are thin EPON sections with our unique PAS staining and TEM photomicrographs of patient skeletal muscle with abnormal lysosomes.   Glycogen Storage Diseases are devastating, rare genetic orphan diseases for which… Read More


Models of Pulmonary Infection

By On July 3, 2018

  CBI has optimized and validated four new pulmonary models that have both immune mediated and infection components.   Model of Nasal Aspergillosis in Rabbits Chronic invasive fungal rhinosinusitis (Aspergillus fumigatus)may occur… Read More


CBI Sponsors Ototoxicity and ABRs in Toxicologic Assessments at the ACT

By On March 2, 2018

The ACT Annual Meeting is the most cutting edge toxicology meeting anywhere!  This year scientists from CBI attended and exhibited at the ACT meeting in Palm Springs CA in November 4-9, 2o17. … Read More


Scleroderma: Tight Skin Mouse Model at CBI

By On October 17, 2017

CBI offers preclinical research studies in dermal and pulmonary fibrosis.  In addition to our validated bleomycin-induced fibrosis models, we also now offer fibrosis studies with the JAX Tight Skin Mouse Model. There… Read More


The (Non)Reproducibility Crisis, Part 4

By On August 18, 2017

Harris cites numerous examples of Type I error (also known as false positives) in efficacy studies throughout the book—i.e., drugs that worked in disease models but then failed in human trials.  Chapter… Read More


The (Non)Reproducibility Crisis, Part 3

By On August 9, 2017

In our previous post, we discussed NPR science journalist Richard Harris’s general critique of animal research in his book Rigor Mortis, but there is more to be said.  If animal models are… Read More


The (Non)Reproducibility Crisis, Part 2

By On August 2, 2017

In Part 1 of this series, we gave a general introduction to the problem of non-reproducibility of preclinical studies and some reasons why CROs including Comparative Biosciences are somewhat immune to it.… Read More


The (Non)Reproducibility Crisis, Part 1

By On July 25, 2017

John Ioannidis’s 2005 paper, “Why most published research findings are false”[1] set off a cascade of discussion, despite its impenetrability, not least because of its sensational title.  Concerns about non-reproducibility have been… Read More


Laser-induced Choroidal Neovascularization in the Mini Pig

By On May 23, 2017

A validated model for posterior segment proliferative ocular disease at CBI CBI is known throughout the Industry as a premier ocular preclinical CRO.  For over 10 years, we have offered established in-house… Read More