Specialized, Customized or Surgical CNS Pharmacology

CBI offers a variety of customized, investigative, and specialized surgical pharmacology and efficacy models centered on the Central Nervous System. These studies maybe hypothesis-driven or requested by regulators, and may require specialized or unusual techniques or methods. If you have a specialized CNS study requirement, our skilled scientists can facilitate the protocol development as well as the conduct of these novel, difficult and specialized projects.

CBI welcomes the opportunity to develop new customized studies and efficacy models. The following are some examples of specialized surgical efficacy and toxicology studies that we can successfully conducted. We will help you design your next unique custom surgical study! Some of our more esoteric capabilities include:


  • GLP and NonGLP CNS toxicity and efficacy-toxicology studies with stem cells, biologics, small molecules, devices, others
  • Pharmacokinetic and toxicokinetic assessments of CSF and CNS tissues
  • Combination efficacy and toxicology studies centered on the CNS. Examples include:

• Anesthesia-induced cerebral toxicity in neonates – check out our publication

• Intracerebral oncology, implantation of intracerebral tumors and treatments

• Intrathecal, intracerebral and intraventicular dosing studies in small animals and dogs – check out our publication

• Meningeal, dural and skull repair and patching

• Stereotaxic administration dosing studies-ex 6OHDA for Parkinson’s, or tumor treatment

• Stent and vascular device deployment

• Combination stem cell and device toxicity and efficacy studies

CNS Efficacy Studies

  • • Parkinson’s disease
  • • EAE, other immune mediated CNS disorders
  • • Stroke
  • • CNS and intracerebral tumors
  • • Spinal cord and brain trauma


Laboratory Capabilities

  • • MRI
  • • CT scanning
  • • Behavioral
  • • Radiology
  • • Histopathology, Immunohistochemistry, Immunofluorescence
  • • Histomorphometry
  • • PCR, Elisa, bioanalytical


Call us for more information:

Contact: Aditya Saxena

Phone: 408-738-9260