Carol_Meschter Blog

Cannabis Pharmacology

Cannabis Preclinical Pharmacology and Toxicology

By On March 14, 2018

Cannabis Toxicology and Pharmacology             Assessment of Cannabis Products for Purity, Effectiveness and Safety. Now that medical cannabis has achieved some degree of legality and public acceptability,… Read More


CBI Sponsors Ototoxicity and ABRs in Toxicologic Assessments at the ACT

By On March 2, 2018

The ACT Annual Meeting is the most cutting edge toxicology meeting anywhere!  This year scientists from CBI attended and exhibited at the ACT meeting in Palm Springs CA in November 4-9, 2o17. … Read More



By On March 2, 2018

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Scleroderma: Tight Skin Mouse Model at CBI

By On October 17, 2017

CBI offers preclinical research studies in dermal and pulmonary fibrosis.  In addition to our validated bleomycin-induced fibrosis models, we also now offer fibrosis studies with the JAX Tight Skin Mouse Model. There… Read More


Toxicologic and Histopathologic Peer Review

By On August 28, 2017

Histopathologic Peer Review (PR) is an important tool in aiding quality and accuracy in the histopathologic assessment of toxicology studies. The peer review verifies and improves the accuracy and quality of pathology… Read More


The (Non)Reproducibility Crisis, Part 4

By On August 18, 2017

Harris cites numerous examples of Type I error (also known as false positives) in efficacy studies throughout the book—i.e., drugs that worked in disease models but then failed in human trials.  Chapter… Read More


The (Non)Reproducibility Crisis, Part 3

By On August 9, 2017

In our previous post, we discussed NPR science journalist Richard Harris’s general critique of animal research in his book Rigor Mortis, but there is more to be said.  If animal models are… Read More


The (Non)Reproducibility Crisis, Part 2

By On August 2, 2017

In Part 1 of this series, we gave a general introduction to the problem of non-reproducibility of preclinical studies and some reasons why CROs including Comparative Biosciences are somewhat immune to it.… Read More


The (Non)Reproducibility Crisis, Part 1

By On July 25, 2017

John Ioannidis’s 2005 paper, “Why most published research findings are false”[1] set off a cascade of discussion, despite its impenetrability, not least because of its sensational title.  Concerns about non-reproducibility have been… Read More


Laser-induced Choroidal Neovascularization in the Mini Pig

By On May 23, 2017

A validated model for posterior segment proliferative ocular disease at CBI CBI is known throughout the Industry as a premier ocular preclinical CRO.  For over 10 years, we have offered established in-house… Read More