Ophthalmic pharmacokinetics research is key to selecting early compounds or chemical structures for further assessment as well as assessing candidates for advancement into human. CBI offers a variety of preclinical ophthalmic pharmacokinetic, pharmacodynamic and biodistribution study capabilities. Our assessment and analysis modalities are fine-tuned to meet the specific requirements demanded in each targeted area of ophthalmologic pharmacokinetic investigation.

CBI is versed in ocular pharmacokinetic studies employing stem cells, contact lens (medicated), punctal plugs, as well as other surgically implanted ocular and intra-ocular devices.

Formulations

  • Cream
  • Eye drop
  • Implant
  • Insert
  • Microspheres
  • Ointment or gel
  • Particle
  • Patch
  • Small/large molecule

Additional formulations and radiolabeled studies are also available.

Routes of Administration

  • Implant or device
  • Intracameral
  • Intrascleral
  • Intrastromal
  • Intravitreal injection
  • Ocular application
  • Periocular injection
  • Retrobulbar
  • Subconjunctival injection
  • Subretinal
  • Subtenon
  • Systemic routes
  • Trans-scleral

Additional routes also include contact lens, punctal plus and other implanted devices.

Sample Collection

  • In vivo
    • Aqueous
    • Blood
    • Feces
    • Tears
    • Urine
    • Vitreous
  • Necropsy: microdissection
    • Choroid
    • Ciliary body
    • Cornea
    • Eyelids
    • Extra ocular muscles
    • Harderian gland
    • Iris
    • Lacrimal gland
    • Lens
    • Nasal lacrimal duct
    • Nictitating membrane
    • Optic nerve
    • Palpebral or bulbar conjunctiva
    • Retina
    • Sclera
    • Vitreous