If you are studying retinal neovascularization, dry eye, inflammation, immune-mediated inflammation, infection, pain, neurodegeneration, corneal damage or glaucoma, then consider using one of our wide variety of validated ocular efficacy and pharmacology models.
In Vivo Methods of Assessment
- Angiography [has image below]
- Aqueous or vitreal protein
- Aqueous or vitreal cell count
- Bengal rose thread tests
- Body weights
- Brightfield [has image below]
- Clinical signs
- Draize scoring
- ERG [has image below]
- McDonald-Shadduck scoring
- OCT [has image below]
- Ocular photography
- Phenol red thread tests
- Phoenix retinal scanner
- Tear break up time tests
- Schirmer tests
- Slit lamp biomicroscopy
*Images courtesy of Phoenix Research Labs, Pleasanton, Calif.
Ocular Pharmacology Efficacy Studies and Models
- Scopolamine-induced dry eye
- Botulinum-induced dry eye
- ConA-induced model
- Glycopyrrolate-induced model
- Benzalkonium-chloride-induced model
- Laser-induced glaucoma
- Water loading
For more information please check out our presentation on our Glaucoma Modeling capabilities.
- LPS-induced acute uveitis- Check out our presentation!
- F40 80-induced acute uveitis
- Albumin-induced conjunctivitis
- Immune-mediated inflammation
- Melanin associated antigen-induced anterior uveitis
- IRBP or S-antigen-induced posterior uveitis
Acute anterior uveitis is a recurrent immune-mediated inflammatory condition involving the iris and ciliary region. Both the ophthalmological presentation and the histologic features are analogous to the human condition.
Imagery of MAA-Induced Anterior Uveitis
|Grade 4 inflammation following MAA treatment Brightfield||Normal eye|
|Brightfield||Optical coherence tomography (OCT)|
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