If you are studying retinal neovascularization, dry eye, inflammation, immune-mediated inflammation, infection, pain, neurodegeneration, corneal damage or glaucoma, then consider using one of our wide variety of validated ocular efficacy and pharmacology models.

Check out our presentation on our glaucoma modeling capabilities to learn more!

In Vivo Methods of Assessment

  • Angiography [has image below]
  • Aqueous or vitreal protein
  • Aqueous or vitreal cell count
  • Bengal rose thread tests
  • Biomarkers
  • Body weights
  • Brightfield [has image below]
  • Clinical signs
  • Draize scoring
  • ERG [has image below]
  • Funduscopy
  • IOP
  • McDonald-Shadduck scoring
  • OCT [has image below]
  • Ocular photography
  • Pachymetry
  • Phenol red thread tests
  • Phoenix retinal scanner
  • Tear break up time tests
  • Schirmer tests
  • Slit lamp biomicroscopy
  • Ultrasound
angiography
Angiography
brightfield
Brightfield
erg
ERG
optical-coherence-tomography-oct
Optical Coherence Tomography OCT

*Images courtesy of Phoenix Research Labs, Pleasanton, Calif.

Ocular Pharmacology Efficacy Studies and Models

DRY EYE
  • Scopolamine-induced dry eye
  • Botulinum-induced dry eye
  • ConA-induced model
  • Glycopyrrolate-induced model
  • Benzalkonium-chloride-induced model
GLAUCOMA AND OCULAR HYPERTENSION
  • Laser-induced glaucoma
  • Corticosteroid-induced
  • Water loading
  • Chymotrypsin

For more information please check out our presentation on our Glaucoma Modeling capabilities.

INFLAMMATION
  • LPS-induced acute uveitis- Check out our presentation!
  • F40 80-induced acute uveitis
  • Albumin-induced conjunctivitis
  • Immune-mediated inflammation
  • Melanin associated antigen-induced anterior uveitis
  • IRBP or S-antigen-induced posterior uveitis
MELANIN-ASSOCIATED ANTIGEN (MAA) INDUCED ANTERIOR UVEITIS

Acute anterior uveitis is a recurrent immune-mediated inflammatory condition involving the iris and ciliary region. Both the ophthalmological presentation and the histologic features are analogous to the human condition.

Imagery of MAA-Induced Anterior Uveitis

grade4Grade 4 inflammation following MAA treatment Brightfield normaleyeNormal eye
brightfieldBrightfield optical-coherence-tomography-octOptical coherence tomography (OCT)

READ MORE ABOUT MAA:

Download the MAA Ocular Presentation
Download the MAA Ocular White Papers
Read MAA Ocular on Dr. Carol Meschter’s Blog
OCULAR PAIN
  • Capsaicin-induced
  • Formalin-induced