Arthritis and Immune-Mediated Studies

CBI offers a wide variety of validated models for the assessment of allergic and immune-mediated disease including arthritis, EAE, colitis, dermatitis, eosinophilic esophagitis and asthma.

We have extensive experience in assessment of arthritis, including collagen-induced arthritis in DBA-1 models, antibody-induced arthritis, collagen and adjuvant-induced arthritis, ovalbumin-induced arthritis and MSU-induced models of gout. Validation data is available upon request.

In vivo assessments may include clinical signs, biomarkers, body weights, food consumption, lameness scoring, joint diameter measurement scoring, plesthysmometry and biomarkers. Histopathologic assessment including special stains and immunohistochemistry are key factors in assessing changes in the joints.

Arthritis Models

  • Adjuvant-induced arthritis
  • Antibody-induced arthritis
  • Collagen-induced arthritis
  • Collagen-induced arthritis
  • MSU-induced arthritis (gout, and included intraperitoneal and air pouch inflammation)
  • Ovalbumin-induced arthritis