Inflammation Pharmacology

Inflammation remains a significant unmet need in patients and companion animals. CBI provides a wealth of validated acute, chronic and immune-mediated pharmacology models, reflecting the strong expertise and experience of our study directors and scientists. We will be happy to provide more information and validation data for our inflammation models.

In Vivo Models

  • Acute and chronic inflammation
  • Delayed type hypersensitivity
  • Local irritation and tolerability

Inflammation and Immune-mediated In Vivo Studies

MSU-induced
  • Air pouch
  • Arthritis
  • Peritonitis
Myositis and nerve crush injury
  • Carrageenan
  • LPS
  • Thioglycolate
Ocular inflammation
  • Heptanol-induced corneal erosion
  • LPS-induced uveitis
  • Melanin-induced immune mediated uveitis
  • Ovalbumin-induced conjunctivitis
  • Surgical incision and healing
  • Suture-induced
  • Suture-induced inflammation
Carrageenan-induced
  • Air pouch
  • Foot pad
  • Peritonitis
Colitis
  • TNBF
  • Oxazalone
  • DSS
Diabetes, obesity and metabolic
  • STZ-induced type I and type II diabetes
  • Zucker, Db/Db, Ob/Ob, and Pound models
  • Other susceptible strains
Delayed type hypersensitivity
  • BCG
  • Drug-induced
  • Hapten-TNBF, etc.
  • Oxazalone
EAE
  • MOG EAE
  • PLP EAE
  • Cuprizone-induced demyelination
Fibrosis
  • Bleomycin-induced pulmonary and dermal inflammation and fibrosis
  • Hepatic
  • Monocrotaline-induced pulmonary hypertension and inflammation
  • Myocardial-doxarubicin-induced fibrosis
  • Renal
LPS-induced inflammation, local and systemic
  • Dermal
  • Ocular
  • Pulmonary
  • Systemic (sepsis or SIRS model)

We also offer models for:

  • Asthma
  • Atopic dermatitis
  • Eosinophilic esophagitis
  • Peritonitis