There is often a need for specialized and complex pharmacology studies, generally to address unanticipated or unusual toxicologic or pharmacological events or to conduct efficacy or pharmacology studies that are of a difficult or unusual nature. These studies are directed, hypothesis driven, and may have specialized or unusual techniques or methods. In some cases they are requested by the FDA or by clinicians.
Examples might include CT or PET scanning, specialized immunohistochemistry, surgical aspects, application of test article surgically, or esoteric blood samples. The skilled scientists at CBI can facilitate the protocol development as well as the conduct of these difficult and specialized projects.
Stereotaxic and intracerebral administration of chemotherapeutic in rodents and dogs
CBI provideshighly specialized administration of chemotherapeutics intracerebrally either by surgical stereotaxic injection or by local administration to rodents, rabbits and dogs. This route of administration is appropriate for assessment of therapeutic modalities for brain tumors such as glioblastoma. In rodents, intracerebral tumors may be induced and treated. In dog and rabbits, the effects of test article administration directly into the neuropyl may be determined. The activity of small molecules and biologics may be determined in either a GLP or nonGLP environment and may include assessments such as clinical neurologic parameters, clinical pathology, toxicokinetics, CT Scanning, pcr, and complete histopathology and immunohistochemistry. For more information, contact CBI.