Past Publications
Dr. James Christenson's Publications

1. J. G. Christenson, K.-K. Chan, R. Cleeland, B. Dix- Holzknecht, H. H. Farrish, Jr., I. H. Patel, and A. Specian, "Pharmacokinetics of Ro 23-9424, a dual-action cephalosporin, in animals," Antimicrob. Agents Chemother. 34: 1895-1900 (1990).

2. H. A. Albrecht, G. Beskid, J. G. Christenson, J. W. Durkin, V. Fallat, N. H. Georgopapadakou, D. D. Keith, F. M. Konzelmann, E. R. Lipschitz, D. H. McGarry, J. Siebelist, C. C. Wei, M. Weigele, and R. Yang, "Dual-Action Cephalosporins: Cephalosporin 3'- quaternary ammonium quinolones," J. Med. Chem. 34: 669- 675 (1991).

3. C.-C. Wei, J. G. Christenson, A. J. Corraz, and D. D. Keith, "(2,3)-Methylenepenicillanic acid sulfone: synthesis and  lactamase inhibiting properties," Bioorg. Med. Chem. Lett. 1: 43-46 (1991).

4. H. A. Albrecht, G. Beskid, J. G. Christenson, N. H. Georgopapadakou, D. D. Keith, F. M. Konzelmann, D. L. Pruess, P. L. Rossman, and C.-C. Wei, "Dual-Action Cephalosporins: Cephalosporin 3'-quinolone carbamates," J. Med. Chem., 34: 2857-2864 (1991).

5. H. A. Albrecht, G. Beskid, J. G. Christenson, K. H. Deitcher, N. H. Georgopapadakou, D. D. Keith, F. M. Konzelmann, D. L. Pruess, C. C. Wei, "Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone," J. Med. Chem. 37: 400-407 (1994).

6. J. G. Christenson, V. Brocks, K.-K. Chan, D. D. Keith, D. L. Pruess, F. F. Schaefer, and M. K. Talbot, "Inhibition of peptidoglycan and DNA synthesis by Ro 23-9424, a dual-action cephalosporin," manuscript in preparation.

7. M. K. Talbot, F. L. Margolis, H. R. Kaback, and J. G. Christenson, "Topology of peptidoglycan biosynthesis in E. coli membrane vesicles," manuscript in preparation.

8. K. J. Kelly, N. E. Tolkoff-Rubin, R. H. Rubin, W. W. Williams, Jr., S. M. Meehan, C. L. Meschter, J. G. Christenson, and J. V. Bonventre, “An oral platelet-activating factor antagonist, Ro 24-4736, protects the rat kidney from ischemic injury,” Am. J. Physiol. 271: F1061-1067 (1996).

Review articles and book chapters

9. E. Squires and J. G. Christenson, "Ro 23-9424," Drugs Future 16: 620-623 (1991).

10. H. A. Albrecht and J. G. Christenson, "Mechanism-based dual-action cephalosporins," p. 207-234. In B. E. Maryanoff and C. A. Maryanoff (Eds.), Advances in Medicinal Chemistry, Vol 1, 1992. JAI Press, Greenwich, Conn.

11. D. D. Keith, H. A. Albrecht, G. Beskid, K. K. Chan, J. G. Christenson, R. Cleeland, K. Deitcher, M. Delaney, N. H. Georgopapadakou, F. Konzelmann, M. Okabe, D. Pruess, P. Rossman, A. Specian, R. Then, C.-C. Wei, and M. Weigele, "Mechanism-based dual-action cephalosporins," p. 79-92. In P. H. Bentley and R. Ponsford (Eds.), Recent Advances in the Chemistry of Anti-infective Agents, 1993. Royal Society of Chemistry, Cambridge, UK.

Papers presented

12. J. L. Roberts, G. Beskid, J. Borgese, J. G. Christenson, N. H. Georgopapadakou, D. D. Keith, D. L. Pruess, C. C. Wei, and R. Yang, "Quinolone-amidino-lactams: Synthesis and biological properties," 30th ICAAC, Atlanta, Ga., October 21-24, 1990, Abstract No. 406.

13. F. F. Schaefer, M. K. Talbot, P. C. Tang, T. L. Robertson, and J. G. Christenson, "The role of AmpC lactamase in the mechanism of action of ester- linked dual-action cephalosporins," 31st ICAAC, Chicago, IL, September 29-October 2, 1991, Abstract No. 953.

14. H. A. Albrecht, G. Beskid, J. G. Christenson, K. H. Deitcher, N. H. Georgopapadakou, D. D. Keith, F. M. Konzelmann, D. L. Pruess, and C. C. Wei. "Dual-action cephalosporins incorporating 3'-tertiary amine-linked quinolones," 31st ICAAC, Chicago, IL, September 29-October 2, 1991, Addtional Abstract, Session 121.

15. J. G. Christenson. "Biological properties of dual-action cephalosporins." Medicinal Chemistry Symposium on Multifunctional Beta-Lactams, 204th American Chemical Society National Meeting, Washington, DC, August 23-28, 1992, Paper No. 12.

16. S. Filc-DeRicco, H. Gmünder, D. Pruess, F. Schaefer, M. K. Talbot, H. Albrecht, and J. G. Christenson. "Mechanism of action of Ro 25-0534, a dual-action cephalosporin," 33rd ICAAC, New Orleans, LA, October 17-20, 1993, Abstract No. 1492.

17. B. Holzknecht, H. Albrecht, and J. G. Christenson. "Pharmacokinetics of Ro 25-0534, a dual-action cephalosporin, in rats," 33rd ICAAC, New Orleans, LA, October 17-20, 1993, Abstract No. 1494.

18. H. A. Albrecht, G. Beskid, J. G. Christenson, K. H. Deitcher, N. H. Georgopapadakou, D. D. Keith, F. M. Konzelmann, D. L. Pruess, and C. C. Wei. "Ro 25-0534: a 3'-tertiary amine-linked dual-action cephalosporin," 33rd ICAAC, New Orleans, LA, October 17-20, 1993, Abstract No. 1495.