CBI provides a range of pharmacology capabilities across a spectrum of indications that ensure reliable results in the drug-discovery process. Assessment and analysis modalities are fine-tuned to meet the specific requirements demanded in each targeted area of scientific investigation.
- Ocular Pharmacology
- Cardiovascular Pharmacology
- Inflammation Pharmacology
- Anti-infective Studies
- Oncology and Xenograft Studies
- Stem Cell and Nanoparticle Pharmacology
All Comparative Biosciences Inc. Pharmacology Studies Include:
- Experienced, highly trained study directors
- Complete and comprehensive documentation
- High quality reports
- Rapid report preparation
- All pathology performed by a board-certified pathologist
- All clinical chemistry reviewed and interpreted by a board-certified pathologist
Ocular Modeling and Pharmacology
Ocular in vivo modeling
One of our newest areas of expertise, CBI offers discovery and development pharmacology studies for ocular indications.
- Retinopathy of Prematurity Model in infant mice and rats
- Laser-induced retinal neovascularization (macular degeneration) in rats and rabbits
- Corneal pockets in rats and rabbits for neovascularization
- Intra-ocular implants
- Ocular inflammation
- Ocular pharmacokinetics and toxicology
- Ocular toxicity or tolerability studies
- Corneal vascularization
- Corneal injury models
Cardiovascular Pharmacology
Cardiovascular in vivo modeling
- Myocardial ischemia and reperfusion
- Aortic banding for chronic congestive heart failure
- Atherosclerosis in ApoE mice, hamsters, guinea pigs, Watanabe rabbits and pigs
- Balloon angioplasty in rats and rabbits
- Stent placement in rats and rabbits
- Stem cell capabilities
- More information on cardiovascular studies
Inflammation Pharmacology
Inflammation in vivo modeling
- Local irritation and tolerability
- Inflammation- acute, chronic
- Inflammation-LPS-induced, DTH, TNBF, CNBF
- Arthritis—Collagen, adjuvant, antibody, LPS induced
- Osteoarthritis—Chemically or surgically induced
- Asthma-ovalbumin induced
- Colitis—DSS, TNBF, others
- Psoriasis
- Diabetes, Fat Metabolism
- CNS-EAE, meningitis, stroke
- Ocular inflammation
- Radiation induced- bone marrow, bladder and colon inflammation
Anti-infective Modeling and Pharmacology
- Mouse protection test
- Neutropenic thigh abscess
- Dermal inflammation and abscessation
- Bacterial pneumonia
- Cytodex bead subcutaneous abscess
- Bacterial endocarditis
- Sepsis; Clostridium diarrhea
- ATCC and custom bacterial strains available
- Mini Tox and Mini PK studies to support efficacy studies
Oncology and Xenograft Studies
- Numerous cell lines validated
- Subcutaneous, intravenous and orthotopic implantantion
- Immunocompromized and immunocompetent rodents, including knockout and transgenics
- Angiogenesis capabilities
- Stem cell capabilities
- Immunohistochemistry and In Situ
- ATCC and custom tumor cells lines
- Tumor growth data managed by LABCAT
- More information on xenograft modeling and cancer research
Stem Cell and Nanoparticle Pharmacology
- Comparative Biosciences provides experience and capabilities in the new and expanding research areas of stem cells and nanoparticle pharmacology
- Stem Cell Pharmacology: tumor biology, cardiovascular and CNS applications
- Nanoparticles: Pharmacokinetics, toxicology and custom pharmacology
All Pharmacology Studies Include
- Experienced, highly trained study directors
- Senior staff with extensive experience in pharmacology, surgery and in vivo modeling
- Complete and comprehensive documentation
- High quality, rapid reports
- All pathology performed by board-certified pathologist
- All clinical chemistry reviewed and interpreted by board-certified pathologist
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