Pharmacokinetics is one of the most important aspects of drug discovery and development process. It is key to selecting early compounds or chemical structures for further assessment. CBI offers a range of pharmacokinetic and pharmacodynamic capabilities across a broad spectrum of indications that ensure reliable results in the drug-discovery process. Assessment and analysis modalities are fine-tuned to meet the specific requirements demanded in each targeted area of scientific investigation.
Screening Pharmacokinetic Studies
- Quick, inexpensive, “mini-PK” studies (compound sparing for rapid assessment of new molecules in rodents)
- Routine single or multiple dose pharmacokinetic studies
- Oral, ocular, dermal, intra-tracheal, IV, IM, SC, IP, joint fluid, short-infusion and other routes of administration including intracranial by stereotaxic injection or infusion
- Small molecules, proteins, antibodies, biologics, scheduled compounds
- Radionuclide studies
 Pharmacokinetic Studies
- Research and GLP IND enabling pharmacokinetic studies
- Protocol driven, with complete and comprehensive reports
- Pharmacodynamic endpoints also available
- Wide range of species including rodents, rabbits, hamsters, guinea pigs, ferrets, dogs and mini-pigs
- Single dose or multiple dose studies of short or long duration
- Oral, ocular, dermal, intra-tracheal, IV, IM, SC, IP, joint fluid, short-infusion and other routes of administration including intracranial by stereotaxic injection or infusion
- Pharmacokinetic-pharmacodynamic studies in disease models such as tumor-bearing animals, infection models, inflammation models, metabolic diseases, and surgical models
- Small molecules, proteins, antibodies, biologics, scheduled compounds
- Radionuclide studies
Dog Pharmacokinetic Studies
- CBI maintains a colony of male and female Beagles as dedicated pharmacokinetic dogs
- Mini PK, research and GLP/IND enabling pharmacokinetic studies
- Clients may choose to use colony dogs or CBI may also maintain dogs exclusively dedicated to a particular client
- Large dogs are also available by request
Ocular Pharmacokinetics
- CBI specializes in ocular pharmacokinetics in multiple species
- Systemic, topical to intact or injured cornea, or intravitreal administration
- Corneal injury models including the hepatanol-induced corneal erosion model
- Single or multiple administration of test article
- Collection of blood, urine, aqueous humor, vitreous fluid in vivo on multiple occasions during the course of the study
- Collection of entire eye, or subparts such as retina, choroid, lens, cornea post mortem
- Small molecules, proteins, antibodies, biologics, scheduled compounds
- Radionuclide studies
- High quality, rapid reports
Pharmacokinetic Studies Include
- Experienced, highly trained study directors
- Senior staff with extensive experience in pharmacokinetics
- Complete and comprehensive documentation and report preparation including analysis with “PK Solutions™” software upon request
- Pathology and clinical chemistry reviewed and interpreted by board-certified pathologist
Analytical Methods
- CBI provides analytical method development and bioanalytical determinations to support pharmacokinetic studies, including unusual matrices such as eye or joint.
- HPLC, MS, LCMS
- Complete and comprehensive documentation and report preparation including analysis with “PK Solutions™” software
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