Comparative Biosciences, Inc. provides a complete range of research services in the area of pharmacokinetic, toxicokinetic, bioavailability, bioequivalence, and ADME studies. We feature rapid study initiation and report preparation to meet sponsor deadlines or milestones. Our capabilities in pharmacokinetics include early exploratory, investigative, or screening studies, cassette dosing studies, juvenile studies, disease model studies, and formal studies that support regulatory submission.
We feature rapid study initiation and report preparation to meet sponsor deadlines or milestones. We comply with FDA, OECD, and ICH guidelines. Our capabilities in Pharmacokinetics include early exploratory, investigative, or screening studies, cassette dosing studies, juvenile studies, disease model studies, and formal studies that support regulatory submission.
Delivery Methods
- Single-dose, multiple-dose, continuous or slow infusion
- Routes: all routes, including unusual routes
- High-throughput cassette screening-up to 5 compounds administered simultaneously
- Sampling: blood, urine, feces, vitreous, aqueous humor, cerebrospinal fluid, bile, semen, saliva, joint fluid, other tissues or fluids.
- Tissue or organ collection and analysis
- PCR tissue collection
Animal Species
- Mice
- Immunocompromized mice and rats
- Rats
- Cotton rats
- Guinea pigs
- Chinchillas
- Gerbils
- Hamsters
- Ferrets
- Pigs
- Juveniles and neonates
- Dogs
- Cats
- Diseased animals/animal models/tumor models
Routes of administration
- Routine systemic
- Dermal/topical
- Ocular (topical, intraocular, periocular)
- Infusion
- Depot
- Mechanical or osmodic pumps
- Intra-arterial
- Intra-articular or bone
- Intranasal
- Intracerebral (stereotaxic)
- Intrathecal
- Intra-tracheal
- Intra-intestinal
- Intra-rectal
- Intravaginal
- Intravesicular
- Surgical routes
- Other unusual routes
Pharmacokinetic Studies in Disease Models
Disease states can alter the metabolism of some test articles as can treatment with multiple drugs. Consequently, pharmacokinetic assessments in disease models and treatment states may be important. We offer custom pharmacokinetic studies in all the animal models and tumor models that CBI offers.
Large Animal and Colony Studies
CBI maintains a standing colony of healthy dogs, cats, and pigs for use in PK studies for our clients. Alternatively, CBI can also maintain dedicated colonies of dogs, cats or pigs specifically for individual sponsors. Dedicated colonies assure the sponsor that PK studies can be scheduled and conducted very rapidly, usually with a 1-2 week turn around between scheduling and delivery of specimens for analytical assessment.