Comparative Biosciences, Inc. (CBI), a premier ocular research CRO, offers a variety of preclinical opthalmic pharmacokinetic, pharmacodynamic, and biodistribution study capabilities. Ophthalmologic pharmacokinetics are key to selecting early compounds or chemical structures for further assessment as well as assessing candidates for advancement into man. Assessment and analysis modalities are fine-tuned to meet the specific requirements demanded in each targeted area of ophthalmologic pharmacokinetic investigation.
Formulations: Small molecule, biologic, eye drop, ointment or gel, insert, particle, implant, patch, microspheres, cream, other.
Routes of Administration: Topical ocular application, intravitreal injection, subconjunctival injection, periocular injection, intracameral, subretinal, intrascleral, transscleral, intrastromal, subtenon, retrobulbar, intracameral, implant or device, systemic routes.
Species: Rabbits (NZW or pigmented) guinea pigs, rats, mice minipigs, dogs
Sample collection
- In Vivo: Vitreous, aqueous, blood, tears, urine, feces
- Necropsy: Microdissection: eyelids, palpebral or bulbar conjunctiva, nictitating membrane, extra ocular muscles, lacrimal gland, Harderian gland, nasal lacrimal duct, cornea, iris, ciliary body, lens, vitreous, retina, choroid, sclera, optic nerve