Comparative Biosciences, Inc. (CBI), a premier ocular research CRO, provides a large variety of validated discovery preclinical ophthalmic research studies including efficacy, pharmacology, or in vivo indications. Our ophthalmologic models include macular degeneration, retinopathies, dry eye, glaucoma, and inflammation. CBI scientists are available to discuss these models in more detail. CBI is also willing to work with our sponsors to develop unique or customized models.
Validated efficacy ophthalmic studies available at CBI include:
- Choroidal neovascularization in mice and rats (laser-induced)
- Oxygen-induced retinopathy in mice and rats
- VEGF-induced choroidal neovascularization in rabbits
- Streptozotocin-induced retinopathy
- Senescent knockout mouse model of macular degeneration
- Melanin-antigen associated uveitis in rats
- Laser-induced episcleral cautery for glaucoma in rats
- Chymotrypsin-induced glaucoma in rabbits
- Concanavalin A-induced dry eye in rabbits
- Botulinum-induced dry eye in mice
- Scopolamine-induced dry eye in mice
- Heptanol-induced corneal erosion in rabbits
- MNU-induced retinitis pigmentosa
- Corneal pocket neovascularization
- LPS-induced inflammation
- Corneal Infection
Angiogenesis Models
Laser-induced retinal neovascularization (macular degeneration) in mice, rats, and rabbits- Retinopathy of prematurity model in infant mice and rats
- Corneal pockets for neovascularization in rats and rabbits
Read more on angiogenesis models
Models of Inflammation
Ocular inflammation is a significant unmet medical need and there are a variety of acute immune-mediated models of inflammation that may be used to assess drug activity.
Acute Inflammation
- LPS-induced inflammation
Immune Mediated
- Melanin-associated antigen-induced inflammation
Read more on MAA-Induced Inflammation
Ovalbumin-induced inflammation
For further information, contact CBI
Corneal Wound Healing Models
Heptanol or chemically induced corneal ulceration in rabbits
Read more on corneal wound healing models
Models of Dry Eye
Dry eye, whether immune-mediated or age related, is a significant unmet medical need. There are several standard models for assessment of dry eye therapy available at CBI.
Rabbit Conconavalin A-induced dry eye
In this standard model of immune-mediated dry eye, the lacrimal gland is injected with ConA. A self-limiting dry eye develops over about 2 weeks. A typical study design includes:
- Groups with at least 6 rabbits group recommended
- Con A injections on Day 0 and Day 3
- Test article administration either intraocularly or systemically
- Daily assessments of photography, Schirmer tear test, tear break-up test, pachymetry, and slit lamp assessment
- Histopathology on eye and adenexal structures
Mouse botulinum-induced dry eye
For more information, contact CBI
Mouse scopolomine-induced dry eye
For further information, contact CBI
Models of Metabolic Retinopathy
Both the db/db mouse and streptozotin-treated rats develop a diabetic type retinopathy over time. For further information, contact CBI
Models of Ocular Infection
For more information on ocular infection, contact CBI.