Comparative Biosciences, Inc. (CBI), a premier ocular research CRO, provides a large variety of validated discovery preclinical ophthalmic research studies including efficacy, pharmacology, or in vivo indications. Our ophthalmologic models include macular degeneration, retinopathies, dry eye, glaucoma, and inflammation. CBI scientists are available to discuss these models in more detail. CBI is also willing to work with our sponsors to develop unique, customized models or GLP efficacy studies.
Validated efficacy ophthalmic studies available at CBI include:
Models of Angiogenesis and Macular Degeneration
Choroidal neovascularization in mice and rats (laser-induced)- Oxygen-induced retinopathy in mice and rats
- VEGF-induced choroidal neovascularization in rabbits
- Choroidal neovascularization in rabbits (laser-induced)
- Streptozotocin-induced retinopathy
- Senescent knockout mouse model of macular degeneration
Read more on angiogenesis models
Models of Inflammation
- Melanin-antigen associated uveitis in rats
- IRBP-antigen associated inflammation in rodents
- LPS-Induced acute inflammation in rabbits and rodents
- Ovalbumin-induced immune mediated inflammation in rabbits
- F40 80-Induced acute inflammation in rabbits
- Corneal infection
Read more on MAA-Induced Inflammation
Models of Glaucoma
- Laser-induced episcleral cautery for glaucoma in rats
- Chymotrypsin-induced glaucoma in rabbits
Models of Dry Eye
- Concanavalin A-induced dry eye in rabbits
- Botulinum-induced dry eye in mice
- Scopolamine-induced dry eye in mice
- Atropine-induced dry eye in rabbit and mice
Models of Corneal Injury and Healing
Heptanol-induced corneal erosion in rabbits- Suture-induced inflammation in rodents
- Corneal pocket neovascularization
Read more on corneal wound healing models
Other Ocular Diseases
- MNU-induced retinitis pigmentosa