Inflammation remains a significant unmet need in patients and companion animals. CBI provides a wealth of validated acute, chronic, and immune-mediated pharmacology models in small animals and pigs as well as for companion animal and veterinary indications, reflecting the strong expertise and experience of our study directors and scientists. We will be happy to provide more information and validation data for our inflammation models.
Inflammation in vivo modeling
- Acute and Chronic Inflammation
- Delayed Type Hypersensitivity
- Local irritation and tolerability
List of inflammation and immune-mediated in vivo studies offered at CBI
Acute skin wheals-inflammatory mediators, LPS, cytokines, chemokines, test drugs
Air Pouch
- MSU
- Carageenen
- Mediator
Allergic and antigen-induced dermatitis
- Flea antigen dermatitis
- House Dust Mite dermatitis
- Ovalbumin-induced dermal inflammation
- BCG-induced dermal inflammation
- Atopic dermatitis
- Other antigens
Arthritis
- Collagen-induced arthritis in mice
- Antibody-induced arthritis in mice
- Collagen-induced arthritis in rat
- Adjuvant-induced arthritis in rats
- Ovalbumin-induced arthritis in rabbits
- MSU-induced arthritis
- Streptococcal cell wall arthritis
Atherosclerosis
- DbDb mice
- High fat-, sucrose- and fructose-fed guinea pigs
- High fat fed rabbits, guinea pigs, swine, hamsters
- Watanabe rabbits
Asthma in rodents and guinea pigs
Atopic dermatitis in laboratory and companion animals
Carageenan-induced
- Peritonitis
- Foot pad
- Air pouch
Colitis in rodents
- TNBF
- Oxazalone
- DSS
Diabetes, obesity and metabolic
- STZ-induced Type I and Type II Diabetes
- Zucker rats
- DbDb mice
- ObOb mice
- Pound mice
- Other susceptible strains of mice and rats
Delayed Type Hypersensitivity
- Hapten-TNBF, etc
- Oxazalone
- BCG
- Drug induced
EAE in small animals
- MOG EAE
- PLP EAE
- Cuprizone-induced demyelination
Eosinophilic esophagitis in rodents
Fibrosis
- Bleomycin-induced pulmonary and dermal inflammation and fibrosis
- Monocrotaline-induced pulmonary hypertension and inflammation
- Myocardial-doxarubicin-induced fibrosis
- Hepatic
- Renal
LPS-induced inflammation-local and systemic
- Ocular
- Dermal
- Systemic (sepsis or SIRS model)
- Pulmonary
MSU-induced
- Arthritis in rodents
- Air pouch in rodents
- Peritonitis in rodents
Myositis and nerve crush injury
Peritonitis
- Carageenan
- Thioglycolate
- LPS
- Ovalbumin-induced conjunctivitis
- LPS-induced uveitis
- Melanin-induced immune mediated uveitis
- Suture-induced inflammation
- Heptanol-induced corneal erosion
- Suture-induced
- Surgical incision and healing
Veterinary
Studies supporting Animal Health Research in companion cats, dogs, pigs, and small animals.
- Arthritis
- Cardiopulmonary
- Inflammation, atopy, allergy, dermatitis
- Metabolic
- Ocular
- Oncology
- Pain
- Parasitic
- Reproductive
- Wound healing
- Devices
- Surgical studies
- Custom studies