Immunohistochemistry (IHC) is a key tool in both early research and later stage development. The histology laboratory at CBI is skilled in the histologic preparation of specialized tissues from a range of both common and unusual research and discovery models in both a nonGLP and GLP environment.
- Standard IHC on tissues from all species from fixed and frozen tissues and cytospin preparations
- IHC staining method development, verification, and validation
- In Situ Hybridization and Human Y Chromosome Staining
- Immunofluorescence (IF)
- Tissue whole mounts with IHC or IF
- Tissue Cross Reactivity Studies
- Histomorphometry and Digital Image Analysis
- Human, primate, and animal tissue bank (fixed and frozen)
The table presents some of the markers commonly used at CBI
| TGFb | Apoptosis/cell death | KI67 |
| MHC | Lymphocyte Markers | Stem Cell Markers |
| Neuromuscular junction | Inflammatory Markers | Collagen |
| Tumor markers | Vascular Markers | CD4, CD8, CD35, CD68, CD31, CD34 |
| Microglia | Smooth Muscle | Tissue Factor |
| PCNA | BrDU | Factor VIII |
| Macrophages | Glial Fibrillary Protien | Vimentin |
| VAChT | SV2 | Synaptophysin |