General

Atopic Dermatitis (AD) is an inflammatory skin disease that frequently occurs in subjects with personal or family history of atopic disease.

  Four hypertrophic scars on the ventral side of a rabbit’s ear 4 weeks’ post-wound.   Hypertrophic Scar Formation in Rabbits Hypertrophic scar (HS) formation is a skin fibroproliferative disease that occurs following a cutaneous injury, leading to functional and cosmetic impairment. To date, few therapeutic treatments exhibit satisfactory outcomes. Hypertrophic scar (HS) formation is a common […]

Our complex immune system evolved to defend the body from pathogens such as bacteria and viruses but it can also be harnessed to fight cancerous and pre-cancerous cells. Its most potent weapons are T cells which can track down abnormal cells and eliminate them through the utilization of T cell receptors (TCRs) – clusters of proteins on every T cell that identify specific antigens displayed on the outside of cells.

Biocompatibility and Devices Research Biocompatibility is the ability of an implant material to function in vivo without eliciting detrimental local or systemic responses in the body. Prior to their use in human fracture fixation, biomaterials undergo tissue and animal testing to determine their safety and efficacy. Here at Comparative Biosciences, Inc. We offer a range of safety […]

Thermal and UV burns represent an unmet medical need, particularly in defense or military settings.  CBI has a number of humane, validated and optimized superficial, partial thickness and full thickness burn models in rodents and pigs, including mini and Duroc pigs.  We have evaluated a number of therapeutic regimes including biologics and stem cell treatments […]

We offers a range of acute and chronic surgical models
for use in any drug metabolism pharmacology or safety study type.

Spinal Trauma in Rodent Studies at CBI A long-standing goal of spinal cord injury research is to develop effective spinal cord repair strategies for the clinic. Here at CBI, rat models of spinal cord injury provide an important mammalian model in which to evaluate treatment strategies and to understand the pathological basis of spinal cord […]

  Atherosclerosis of the Carotid Artery Treatment for severe carotid stenosis involves eliminating the artery blockage. The most common way to do that is with a surgery called “carotid endarterectomy.” This is performed by making an incision along the front of the neck, opening the carotid artery and removing the plaque. This procedure is done to restore normal blood flow to […]

Intravesicular Toxicology, Pharmacokinetics and Efficacy Studies