Model of Murine Hypersensitivity Pneumonitis (Farmer’s Lung)
Murine models of pulmonary hypersensitivity and inflammation are important for the assessment of novel therapeutics and diagnostics, as well as for the study of disease pathogenesis. CBI has developed and validated a murine model of hypersensitivity pneumonitis (“Farmer’s Lung”) induced by the organism Saccharopolyspora rectivirgula. In this model, the repeated intrapulmonary introduction of S. rectivirgula induces a robust, uniform and marked inflammatory response in the lung characterized by large multifocal chronic granulomas throughout the lung.
Endpoints may include:
- Immunohistochemistry and special stains
- Clinical pathology
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