CBI offers validated models for the assessment of Atherosclerosis and Hyperlipidemia.
Progression and regression studies in ApoE mice
The effects of a test article on aortic plaque formation and lipidemia may be investigated using either a progression or regression study in ApoE Mice fed a High Fat Diet. Mice are placed on the diet from 6-16 weeks and the test article is administered. End points include blood lipids, cholesterol, and triglycerides, as well the assessment of formation of plaque (plaque burden) in the aortic sinus. Assessment of plaque may be conducted using a Paigen type method with histomorphometry.
Hyperlidemia in high fat fed Watanabe rabbits
The effects of a test article on blood lipidemia, liver lipidosis and plaque formation may be investigated using either a progression or regression study in Watanabe rabbits fed a High Fat Diet. Rabbits are placed on the diet and the test article is administered. End points include blood lipids, cholesterol and triglycerides, liver pathology, and assessment of formation of plaque in the aorta.
Hyperlipidemia in high fat fed hamsters or guinea pigs
Both hamsters and guinea pigs become lipidemic and develop Atherosclerosis when fed a high fat diet. The effects of a test article on blood lipidemia, liver lipidosis and plaque formation may be investigated using either a progression or regression study in hamsters and guinea pigs fed a High Fat Diet. Animals are placed on the diet and test article is administered. End points include blood lipids, cholesterol and triglycerides, liver pathology, and assessment of formation of plaque in the aorta.