CBI offers validated models for the assessment of immune mediated disease including arthritis, EAE and colitis.
Arthritis
CBI has extensive experience in assessment of arthritis in mice, rats, and rabbits, including collagen-induced arthritis in DBA-1 mice, antibody-induced arthritis in mice, collagen and adjuvant induced arthritis in rats, and ovalbumin-induced arthritis in rabbits. Life assessments may include body weights, food consumption, lameness scoring, joint change scoring, plesthysmometry, and blood work. Histopathologic assessment is a key factor in assessing test article activity on the joint changes.
- Collagen-induced arthritis in mice
- Antibody-induced arthritis in mice
- Collagen-induced arthritis in rat
- Adjuvant-induced arthritis in rats
- Ovalbumin-induced arthritis in rabbits
For more information, contact CBI
Experimental Allergic Encephalomyelitis
CBI has extensive experience in assessment of Experimental Allergic Encephalomyelitis (EAE) as a model of MS in humans. Progressive or relapsing remitting forms in both mice and rats may be induced using MOG and PLP respectively. Life assessments may include body weights, food consumption, neurologic scoring and blood work. Histopathologic assessment is a key factor in assessing test article activity on brain and spinal cord lesions.
For more information, contact CBI
Colitis
CBI has extensive experience in assessment of colitis as a model of inflammatory bowel disease in mice and rats, including DSS, TNBS, and oxalazone-induced methods. Life assessments may include clinical observations, body weights, food consumption, and blood work. Histopathologic assessment and colon weights are a key factor in assessing test article activity on the colonic mucosa.
Asthma in Guinea pigs;
For more information, contact CBI.
For information on DTH, Guinea Pig Sensitization, and other dermal immune mediated studies, see our information on Dermal Pharmacology.